Quality Standards
TAG Copenhagen has strict quality standards defined for each probe it manufactures. Every oligo is quality control tested using meaningful assays to ensure that it meets these quality standards.
TAG Copenhagen is among the first DNA synthesis providers in the world to offer a free of charge MALDI-TOF mass spec analysis on every single oligo being synthesised (up to 50 bases). TAG Copenhagen uses a Voyager-DE MALDI-TOF from ABI for the QC.
Oligos longer than 50 bases are always purified by RP-HPLC in order to improve the quality of the delivered product. HPLC purification is included in the price for all long oligos.

MALDI-TOF Mass Spec.
TAG Copenhagen has now introduced MALDI-TOF mass spec analysis on all oligos up to 50 bases. The MALDI-TOF analysis verifies the MW of every single oligo analysed. Further it is possible to estimate the amount of n-1 products and even depurinated products. If salts are present in the product this will be shown on the spectra too. Only MALDI-TOF reveals the true quality of the purified product.
TAG Copenhagen is one of the very first DNA synthesis providers in the world to include QC by MALDI-TOF free of charge on all oligos. Most DNA synthesis providers have started to use MALDI-TOF on every batch of oligos they synthesise - at TAG Copenhagen we do the MALDI-TOF analysis on every single oligo. The MALDI-TOF analysis is now fully integreted in the robotic process in the lab.

Trityl Monitoring
Trityl monitoring occurs during the synthesis process and is a general indication of its success or failure. With each base addition, a trityl is released that is somewhat indicative of the base coupling reaction efficiency. TAG Copenhagen monitors trityls using an online absorbance trityl monitor to ensure the successful addition of each base in the oligonucleotide.

RP-HPLC purification
TAG Copenhagen offers free of charge HPLC purification for all oligos longer than 50 bases. On HPLC the full length product is seperated from failure sequences using a gradient of buffer and acetonitrile. An on-line computer makes an automatic peak detection and a robot collects the purified product.